Mostly Animal Pictures

Sometimes the kids sneak into the frame when I am taking pictures of the animals. Like this one where Ouiser was giving Zeus’ undercarriage a good sniff while Evan is holding him up to show how tall she is (we call her “Long Kitty”). Or when Ouiser pretends she is a lap dog. The kittens are no longer tiny. They roam the outside at will and mostly come in for the night. They don’t usually stay still long enough for photos unless they are sleeping – which they do a lot of.

Summer changed to Fall. Ouiser went for two weeks to sleep away training camp and came back amazingly trained. Jo went to Hawaii for a birthday and returned Covid-free but with no other obvious improvements unlike Ouiser. We got Jo a new set of wheels (to replace her Land Rover) and two kayaks and we went camping a couple of times. We carved pumpkins for Halloween and the kids did a bit of trick-or-treating while the parents socially distanced and imbibed Johnathan’s special cocktails. Evan dressed as a jawa and I was a tusken raider, and we made our own costumes. School is coming along. Vivian had in-person school till Thanksgiving and then her school shifted to online in anticipation of people behaving badly. Evan’s school is still one week on and one week off, alternating between in-person and online. They aren’t doing amazing shit, but they are keeping it together which is enough for Jo and me this year.

Vivian joined Gilbert’s Youth Gazelles – a running group at Town Lake headed by a runner and coach from Burundi. Sometimes I drop her off and walk the loop around the lake before picking her up. That means I take lots of photos of downtown and the lake. Yes – I am easily distracted.

A Vaccine

Today a 90 year old lady in Coventry, England, became the first person in the UK to get a production version of the BioNTech/Pfizer vaccine. Meanwhile, earlier this week, a Wyoming state health official, Igor Shepherd, who works on the state’s covid response, said that the “so-called pandemic” and efforts to develop a vaccine are plots by Russia and China to spread communism worldwide. He is apparently not alone by a long shot.

Here’s my two cent understanding of how an mRNA vaccine works (Michelle – could you please run it by Alu and see if it is somewhat correct).

photo by Getty Images

The corona virus consists of a genome of RNA enclosed in a protein envelope with spike proteins on its surface, giving it that special sucker-ball look. These spike proteins are what allows a virus to stick to a corresponding receptor protein on a human cell surface, and then poke through the cell wall and transfer its genome to the host cell. Once inside the host cell, the genomic RNA replicates itself and it hijacks cellular organelles called ribosomes within the infected host cell to make viral proteins including new copies of the spike protein. It can do both because it is a strand of RNA which is both a genome and a messenger RNA. The proteins and the replicated RNA self assemble into new virus which infect more cells in our bodies. But it isn’t all one-sided. Our adaptive immune system marks the spike protein that is causing all the fuss as an antigen. In a series of amazing molecular orchestrations via different immune cells, our body produces yet another very specific matching protein called an antibody. The antibody can latch on to the antigen like one puzzle piece fits into another. If all the spike proteins in the invading virus are locked by antibodies in this way, the virus can’t use its spike proteins to invade cells. Additionally, the antibodies, once latched to antigens, mark those virus for destruction by other immune cells. This is how the body fights the virus. The adaptive immune system has a memory. If your body encounters the antigen in the future, it quickly recognizes the antigen and produce lots of antibodies to bring to the battle, thereby preventing future infections. Incidentally, antigen tests for covid work by looking for the corona virus antigens in your tissue sample instead of the virus genetic material itself. Because it is easier to test for a protein, these tests are faster, but they are also less accurate – you may be infected but you may not yet have sufficient antigens to produce a positive covid test.

Back to the vaccine. So the BioNTech and Pfizer scientists first synthesized the mRNA strand that encodes for the corona virus spike protein. This is a portion of the corona virus genome but it isn’t grown from the virus. Instead it is built from scratch. The mRNA strand is then wrapped in a tiny oily bubble made of lipid nanoparticles. When sufficient number of these are injected into your arm, some of these bubble wrapped mRNA packages bump up against your cells and fuse with them and release the mRNA into that cell. Once inside the cell the mRNA does what mRNA do – it instructs the cell’s ribosomes to make the protein encoded in its structure – which happens to be the corona virus spike protein. And once your vaccinated host cell produces the spike protein in sufficient quantities, your body’s immune system takes over and produces antibodies just as if you have a covid infection. Because this bit of mRNA knowns only how to make the spike protein, it does not know how to replicate itself or make the other proteins needed to assemble a virus. So you can’t get infected. But bam, you are protected against infection.

These vaccines are feats of modern science. They wouldn’t be here without the rigor and expertise that the anti-science crowd berates. Government organizations like the NIH, the CDC, and the FDA in the US and corresponding organizations in other countries, and private research and pharmaceutical companies from around the world, and billions of taxpayer dollars have funded the research and the build-up of the manufacturing capacity for this vaccine. Thousands of scientists have worked through the pandemic to get here. There are still unknowns. This is the first time that a vaccine using mRNA has been approved for human use. Are there long term side effects or problems? Can we afford to wait to find out?

The covid vaccine may be the defining scientific moment of my time. Unless it turns us all into controllable communists. Is the vaccine right for you? Here’s a simple test: if you agree that Trump won this election, don’t get the vaccine. Instead, gather in large numbers indoors without masks. If you are concerned about state or local laws the limit how many people can meet, don’t worry. Go meet at church and you’ll be fine. Really. The Supreme Court said so.

Champions

Evan plays soccer. It’s the only sport he’ll touch with a ten foot pole. And he’s not that into it. When we returned to Austin after traveling earlier this year, his old club called and asked if he was ready to rejoin. We were invited back by a parent of Evan’s old teammate who was putting a team together. Evan ended up with half a dozen of his old friends. The team would be a Select team in the club and play in the Super League of Austin along with other teams whose parents were too lazy to travel for weekend soccer games to neighboring towns which is a requisite to join the Elite league. We thought it would be a good and somewhat safe way for Evan to get some exercise and socialization during the pandemic. The club is pretty serious about its pandemic protocols, and in any case everything happens outdoors.

Evan’s coach quit after two weeks and was replaced by this famous soccer personality in Austin – the fields that Evan started playing soccer at are named after this guy. He’s a gruff old Argentine with little time for social graces. He put Evan in the central defender position and never substituted him out during games even though the rest of the players rotated in and out. This was our first indication that may be Evan was better than we had given him credit for. Evan of course thinks he’s the best. Here’s a clip of him saying why he should be admitted to St. Stephen’s school for middle school. No, we didn’t use this particular clip.

So yesterday the team finished its season without a single loss in the pre-season, regular season, and the tournament, ending up as champions. I think all the parents were surprised in the beginning when the wins started coming in, and then rather enjoyed the proxy glow of victories. Needless to say we are proud of our boys and how well they played. There were a couple of excellent players in the team (and they aren’t named Evan), but the whole team got together and did it while having loads of fun. In fact they had fun, and ended up winning. 

The crusty coach mostly barked short stucco phrases at the kids during games and practice. Unforgiving comments, I thought, but always aimed at improving the player. And the kids didn’t mind being held accountable. Yesterday while handing out medals he spoke more words than we heard all season. The coach thanked Henry who had broken a foot during practice four weeks ago but continued to come to every game anyway. He hobbled to the sidelines on his crutches and supported his team. Then the coach thanked Vinny, who he said was always helpful and had a great heart. He thanked the whole team without singling out the better players. I thought this was a class act. I hope the kids learned something from it. 

Evan started the season with six friends and ended up with the whole team of friends. Along the way, some players had the opportunity to jump ship to teams in the Elite league. But they said no and stayed with this team. They will be back in a month together again for the spring soccer season, and I hope their crusty coach stay too. Besides, he gave me a medal yesterday for my duties as a team manager. Class act all the way : -)

A Lone…

…ranger? …wolf? …some dove? …star? …ly hearts club band? The family went back to the White Wooden House yesterday after Thanksgiving. The moon is startlingly full and the color of butter. Later tonight there will be a partial lunar eclipse. One tiny planet’s shadow will soon fall on an even smaller object across a couple of hundred thousand miles of empty space for a few tens of minutes. Some members of a somewhat less-hairy two legged species of apes who inhabit the planet will look up at the skies in the middle of the night and get excited.

I enjoy being here alone. Perhaps because it is an option just like when I had a vegetarian lunch the other day, knowing there was bacon in the fridge for breakfast the next morning. Having established that I’m not a true loner, I’m going to admit that I’m not even really alone. They left Ouiser with me. Ouiser is not a loner. All day she played, ran, slept, ate, pooped, chewed, barked, rested, and most recently, farted, all never more than a few feet away from me. I took a break from my activity for the day – planting wildflower seeds – to take numerous photos and videos of Ouiser. I won’t share them all with you, but I will share some.

The kids have noticed that I more or less stopped taking pictures of them since we got the pets. What can I say? Ouiser is much better looking…

Speaking of being alone, here’s a thought. Imagine where no one interacts with anyone outside of their family for eight weeks (assume a worst case serial infection scenario of two weeks per person and a family size of four). Each family stays absolutely alone. So, no mingling at schools or hospitals or nursing homes or grocery stores or Amazon delivery or pharmacies or the police or gas stations or gyms or restaurants or bars or drivers license places or prisons or homeless shelters or hotels or cruise ships or airplanes or at football games or church or Sturgis or military bases or weddings or Kim Kardashian’s birthday party. Would the virus have disappeared from the human species by the end of those 8 weeks? I’m not saying this is practical. But I have questions. Can/could we do some version of this with more time thrown in for where people inevitably have to interact? And if my yard doesn’t look like this come spring, should I ask for a refund (native wildflower seeds are more expensive per pound that aged tenderloin steaks)?

Paper Cranes

In Walter Dean Myers’ The Treasure of Lemon Brown, Brown says “Every man has a treasure,” and I may not be a man, but I do have a treasure. It was given to me by an old man standing outside a museum.

I wince as I dig through my bag, finding only crumbs and stray dirt until my hand brushes against a folded paper. It’s dry and cool to the touch, and has a slightly glossy feel to it. As I retract my hand from my bag, the folded paper held gingerly in my palm, I can see that it’s a paper crane. I toy with its delicate wings, slipping its waxy surface between my fingers. It’s folded out of a black paper, so dark it seems to suck all the light from the space around it. It’s of an incomplex design, but holds a certain elegance in its simplicity. It’s head tilts down, bending its long neck gracefully, as if paying respects to the lost lives it symbolizes. I gaze at it as I am transported back to when I first received it.

It was chilly, but not cold, and the wind nipped playfully at me through the thin fabric of my dad’s sweatshirt, tugging on strands of my hair, inviting me out into the grey city. Everything was quiet, as if the town itself was mourning its dead in silence. My fraying tennis shoes padded softly on the brick ground. The cold stung the barely dried tears on my face. Like everything else in Japan, the city was neat and clean. The trees lined the streets, perfectly spaced and groomed, rounded on the tops, like mushroom clouds.

Fresh tears leaked from my eyes as I replayed a gruesome slide show in my head. Images burned into my mind, like kimono patterns burned into little girls’ skin. Husbands with missing arms weeping over the charred bodies of their wives and children. Faces marred beyond recognition, skin practically cooked. They don’t show you that in school, the way it moved like a tidal wave of superheated air, so fast you didn’t have time to scream. They don’t tell you how it started fiers so intense , they could suck you into their inferno. They didn’t tell me. Now I’m walking out of this museum with tears in my eyes and my head bowed in shame, and yet, an old man with a weathered face and a pair of forgiving eyes is slipping a paper crane into my hand.

[Vivian wrote this yesterday for a short writing assignment for her Language Arts class. I am glad to see an occasional tangible dividend of our traveling, which seems light years away. The experience Vivian recollects here happened in Hiroshima in February. I’m also blown away by what a great teacher and dedicated school can do. Four years ago Vivian couldn’t write more than a couple of sentences without getting frustrated – though her head was bursting with ideas she wanted to express. Here’s a photo of the old Japanese man who gave the kids their cranes of peace in Hiroshima. Vivian is wearing my Pilani sweatshirt.]

I didn’t say we should….

Kill him!

Vivian is our bringer of memes from the world on Instagram. She found this jewel the other day. Evan thought it was the cleverest thing he had heard all day. Try saying this and emphasize a different word each time:

I didn’t say we should kill him.

I didn’t say we should kill him.

I didn’t say we should kill him.

I didn’t say we should kill him.

I didn’t say we should kill him.

I didn’t say we should kill him.

I didn’t say we should kill him.

After the laughter subsided at the dinner table, the kids agreed that subtilty matters!

Falling

Evan took a good hit last weekend during a league soccer game. He collided with a bigger kid whose shoulder or elbow got into Evan’s chest. He went down like sack of flour. I stood on the sidelines wondering if the ref would blow her whistle and the coach would trot over to check him out while the other players took a knee and waited. It happens every few games to someone. For 10 year olds, soccer is a full contact sport.

But Evan got back up and in the game almost instantly, rubbing his chest and taking shallow breaths. He was winded but otherwise fine. I asked him about it when we walked back to the car after the game (which they handily won). He said that Coach Steven from three years ago had taught them the importance of getting up quickly and getting right back into the game. The coach famously crept up unexpectedly on the kids and pushed them over during practice to teach them how to fall and roll right back up. Since then, Evan, as a matter or pride, minimizes his downtime after a fall. What an amazing lesson to learn, I thought.

About 16 months ago when we were on Day 3 and 4 of a hike up Kilimanjaro, Aaron caught some sort of a stomach bug. That night he couldn’t eat dinner and crawled into the tent looking green. The next day we go up to 16,000 feet. We started the day by going up the Barranco Wall, which looked very daunting from our camp.

The morning was morose. But after a huge song and dance with lots of clapping and jumping, our support crew perked us up. As we slowly (“pole-pole” in Swahili) clambered up the Barranco Wall it didn’t seem so bad after all. Aaron sat down where he could. The rest of the day’s hike wasn’t bad either. The next morning Aaron looked better. When we started our final ascent at midnight that night Aaron was back in usual form and beat me to the summit by an hour.

Aaron and Evan did the same thing in different time scales. They got knocked down and they got back up – fast. They were on their feet when it mattered. They both showed resilience.

Countries too can be resilient. Neither the most powerful military nor the biggest treasury (well, a treasury that can borrow the most) were able to help us deal with the corona virus. American competence and advanced science and technology, our staples, could have stepped in, but they were hobbled. The leadership, with the explicit mandate of its voting base, smothered the scientific community, and created a lack of trust in the government (precipitated strangely by a president who heads the government), making it difficult for the competent to do their jobs. So we fell like a bag of dicks. Even defendable places like Hawaii look more like Nebraska than New Zealand. To get back up we must recognize that we are down. And we must agree on which way is up. Should we make American even greater again, again? Or should we chart a new course to a future that isn’t some faded sad replica of an old whitewashed patriarchal christian past? It is too bad that we can’t have Coach Steven creep among nations, pushing us down during practice to teach us how to jump back up.

Another Month

The pod arrived last month – a giant white box that held our worldly belongings while we were traveling. Jo had filled it with what she hadn’t given away to Goodwill. Then a storage company carted it away to a climate controlled building. Last month, like a boomerang, it came back to our driveway. I unlocked it, raised the shutter in the back and took a look at what we had lived without for the last year. By weight, it is mostly books. We’ve moved the boxes from the pod to the garage. But the poor White Wooden House needs some tender love and care before we unpack the boxes.

Something broke in the kid’s bathroom flush and flooded Evan’s bedroom. The floor had to be ripped out and new one installed and then the rest of floors refinished. The paint needed touching up. A new bathroom flush finally got here after a transatlantic voyage but the delivery guy dropped it on our driveway and another one is on order. The flush sits inside the bathroom wall, so the wall has been torn out. We need a new kitchen oven. Two of the air-conditioning systems broke over the same weekend. One was easily fixed but the other will be replaced along with ducts in the attic. The internet works intermittently. The refrigerator is on the blink. But bit by bit the house is being put back together, mostly by Gunaraj. Having things is complicated. It was certainly easier to live out of backpacks in hotels and other peoples’ homes. But ready or not, here we are, back in Austin.

The kids have settled back to school pretty seamlessly. Evan’s school alternates between a week of online and a week of in-person classes. He has rejoined his soccer league and is enjoying playing. So far they haven’t lost a game – which has caused a serious case of swollen-headedness. Speaking of heads Vivian has colored hers flaming red. The procedure was performed by another 13 year old – what could go wrong? She is back in school, and is ecstatic to be back with her friends. She and a friend joined a kids’ running group at Town Lake.

Jo and my return to Austin has been more uneasy. We had excuses. We couldn’t let Ouiser trample through the white wooden house till the newly-refinished floors had a chance to properly cure. Then the cats needed to be micro-chipped before letting them loose in Austin. Now is seems like we are using the Canyon Lake house as a mid-week refuge by turn. With the rains from tropical storm Delta, everything is green and blooming. Ouiser likes to frolic through the tall grass stems when they sway in the breeze. In the middle of last week I sat outside and enjoyed the day and smoked two pork shoulders and a rib for eight hours while Ouiser licked the dripping grease off the smoker. I found this giant moth with eye-like markings on its wings and intricate feathery antennae.

Outside our little privileged town and country bubble, the dumpster-fire-train-wreck that is 2020 rages on. While I would rather rub my eyeballs with a dull cheese grater than see Trump debate, friends from around the world had plenty of funny things to say about it. And a handmaid has joined the alleged rapist (make that two) who will together write majority opinions at the supreme court for the remainder of my life. People agonized with why Mitch McConnell would ram through a lifetime supreme court nomination days before a presidential election after adamantly opposing a previous similar nomination because it was only six months away from the 2016 presidential election. Shankar Vedantam has an answer. In a recent podcasts of The Hidden Brain, his guest, psychologist and professor Linda Skitka, explained it this way.

If you like cheese on your pizza and I like pepperoni, we can both live with that. We can be friends. We are even okay with being each other’s children’s teachers and coaches. Because differences in preferences are okay. If you don’t eat beef and I don’t eat pork, we can still be friends. Differences in normative conventions like driving on different sides of the street in different countries and conflicting religious dietary rules are also okay. But if you support systemic racism and I don’t, we have a difference in moral convictions. Everyone is sure of their moral convictions. They are therefore also sure that those who oppose these views are immoral and wrong. We achieve a 2+2=4 type clarity and certainty about things that are often not objective and therefore subject to multiple opinions.

Jo summed up her feelings about racism this using a popular meme about pizza toppings (credit to funny.co for this version). A few years ago, someone I know who is against abortions invited his friends on facebook to de-friend him if they felt otherwise – and many did. There is almost nothing that can change a moral conviction I hold because I feel it in my bones. And as it requires no evidence, no evidence can shift it. Two years ago on Valentine’s Day, a shooter armed with a semi-automatic rifle shot and killed 17 people at the Majory Stoneman Douglas High School in Parkland, Florida. If you are a staunch 2nd Amendment supporter and worry that “the government is coming for your guns”, that’s one thing. But if you morally believe that anyone should be allowed to own guns and ammunition without restrictions, your choices are limited when you learn that a troubled underage youth is able to legally buy a semi-automatic weapon that he then uses in his rampage to kill 14 year old students at a school. One option you do have is to dive into a wild conspiracy theory conveniently provided to you. Instead of admitting that some gun purchases may be dangerous you are willing to accept a theory that the whole school shooting is an elaborate hoax put on by parents, school administrators, hospitals, doctors, nurses, funeral homes, students, the police, and journalists who are doing all this just to make your god-given right to bear arms look bad. This suddenly gives you the license to become the enraged victim and to rail against the devastated parents who are grieving the sudden violent death of a child. People who feel this way are extreme but not rare. The force of a moral conviction is strong among us all, even if we all don’t go as far as these people do.

Enter a culture where issues are moved into the moral realm to manipulate us. Guns, belief in systemic racism, abortions, climate change, immigration, and even mask-wearing have become morally right or wrong. These issues – some of which are scientific truths or untruths, and hence not subjective in the first place – become battle grounds for good versus bad in our souls. Once we take a stance we are stuck. The only way out is to face massive internal cognitive dissonance and who wants that. This means that politicians and preachers are free to harvest the benefits of having voters ignore policy by keeping us permanently locked into our silos of moral rights and wrongs. While it may be too late for us to extract ourselves from this moral tarpit, we must teach the next generation to be critical thinkers. To stop and put issues in their place before issues put them in their place. To be immune to psychological manipulation.

I went to a secular school growing up. We took that definition to mean all religions and beliefs are okay. Our principal read a prayer or a thought every morning at assembly from an assortment of religions and philosophies. But this is the one (by Rabindranath Thakur) that I and most boys from the Hyderabad Public School remember the best and can recite from memory forty years later:

“Where the mind is without fear
and the head is held high,
where knowledge is free.
Where the world has not been broken up into fragments by narrow domestic walls.
Where words come out from the depth of truth,
where tireless striving stretches its arms toward perfection.
Where the clear stream of reason has not lost it’s way
into the dreary desert sand of dead habit.
Where the mind is led forward by thee
into ever widening thought and action.
into that heaven of freedom, my father,
let my country awake!”

Yesterday a certain 10-year old in an online zoom class was asked by his teacher to find an example of a fact and another example of fiction. He picked the general theory of relativity and god. Dare I hope : – )

Damed Lies and Statistics

It has been said that there are three kinds of lies: lies, damned lies, and statistics. It has also been said that Trump lies like other people breathe. This habit unfortunately makes it difficult for him to be effective against Covid. The little strand of RNA doesn’t care about “alternate truths”. Years from now, Vivian and Evan, you will wonder why we faired so poorly against this bug. Why other countries did so much better. This New Yorker cover from March sums it up.

When you are faced with a tidal wave of shit heading towards the fan, it is hard to find the individual turds for proverbial forest. But here’s a story of a very small turd on its journey towards the air circulation device dangling from the ceiling: a damned lie about statistics! Stick with me for a few minutes while we skim through basic immunology and some arithmetic.

If you survive an infection, it is because your body’s immune system produced a type of protein called an antibody that helped you fight the infection. In the case of Covid, the antibodies stick to the coronavirus at the very same spikes that the virus uses to enter your cells, thus preventing the virus from entering your cells. Your immune system retains a memory of how to produce these antibodies. If you have a future infection, the production of antibodies ramps up quickly, helping fend off the infection. It takes time to recognize a foreign body and make an effective antibody. Someone who has a fresh infection of Covid may not yet have her own antibodies. If she could get some of your antibodies, she may be temporarily protected against the virus. If you donate your blood for helping others, the antibodies and the liquid part, called Covid-19 convalescent plasma (CCP), is separated from the rest of your blood and injected into a Covid patient in need.

Here’s a quote from Dr. Stephen M. Hahn, the commissioner of the FDA from Sunday. Not from a guy whose cousin knows a janitor at the FDA. The Head of the FDA.

“Many of you know I was a cancer doctor before I became FDA commissioner. And a 35 percent improvement in survival is a pretty substantial clinical benefit. What that means is — and if the data continue to pan out — 100 people who are sick with covid-19, 35 would have been saved because of the admission of plasma.”

This 35% number was repeated by the President. Yes – it would be criminal to not use CCP with these numbers. You would understand why the FDA issued an Emergency Use Authorization (EUA) for Covid convalescent plasma. EUAs are precisely designed for something as miraculous as this. The FDA is effectively saying: go ahead and start saving lives while the scientists keep checking on the safety and benefits. It’s too important to wait!

Last week the heads on two other government organizations, the National Institute of Health, and the National Institute of Allergy and Infectious Diseases (Doctors Collins and Fauci respectively) told the FDA not to issue the EUA. They said that the data to support plasma was too weak. How on earth could they say that about convalescent plasma when it is saving 35 people out of every 100 sick people?

Unfortunately there hasn’t been enough time or plasma to run a nice randomized clinical trial to test the safety and benefit of CCP anywhere in the world. If we had, we would be able say something like this: take 200 people who have Covid. Split them randomly into two groups of 100 each. The first group receives CCP treatment and second doesn’t. X people die in the first group by the time the study ends, and Y people in the second group. If X is heaps less than Y, and X doesn’t have other dangerous side effects, X gets FDA approval to become a drug (my brother, Alu, will tell you it’s a bit more complicated and requires three phases of trials with tens of thousands of test subjects, a small army of scientists and statisticians, and several thousand pages of documentation).

So where did Hahn and Trump’s 35% come from? From this study that hasn’t yet been peer reviewed https://www.medrxiv.org/content/10.1101/2020.08.12.20169359v1.full.pdf. I’ve highlighted the relevant part:

Because there are no randomized clinical tests to fall back on, we must rely on various weaker results. Mayo and other medical organizations around the world have been collecting data on CCP for a while. This data from the Mayo study says that people that received more concentrated plasma (plasma with more antibodies) did better than those who got plasma with lower amounts of antibodies. One week after receiving the high dose plasma, 8.9% had died, while one week after receiving the weaker plasma, 13.7% had died. So if I had two experiments with a 100 sick Covid cases in each, about 9 people die in the first group in 7 days and about 14 people die in the second group in the same time. Now let’s do some simple arithmetic: The first group did 13.7% – 8.9% = 4.8% better than the second. That is an improvement of (4.8/13.7)x100 = 35.04% between the first and second types of plasma treatment. Not, as Hahn stated: What that means is — and if the data continue to pan out — 100 people who are sick with covid-19, 35 would have been saved because of the admission of plasma.

Trump needs a miracle cure for Covid. It’s at least a bit ironic because he has spent the last seven months convincing his people that the disease doesn’t exist or isn’t very harmful. He needs a cure to this non-existent harmless disease before election day. He wishes he could be like Putin and start injecting people with a half baked vaccine that Jared made in the basement. So he has been pressuring the FDA for anything. Issue an EUA for plasma so I can hail it as “a major therapeutic breakthrough on the China Virus” and declare the pandemic over (again). When Collins and Fauci told the FDA that the data supporting plasma was too weak, Trump forced the FDA to act alone. Here’s a link to FDA’s website and a screen grab of the press release. Does this read like a scientific press release headline? How often do they normally mention anything about an “administration” :-)? https://www.fda.gov/news-events/press-announcements/fda-issues-emergency-use-authorization-convalescent-plasma-potential-promising-covid-19-treatment

The scientific discussion about convalescent plasma will continue among researchers till enough data is available. CCP has been used on more than 70,000 patients in the US in the last few months. My friend was instrumental in building the first free plasma bank in Hyderabad to help Covid patients there. Scientists from Wuhan to the middle east are trying to figure out how and when to use plasma to fight Covid. At least one potential vaccine is taking this route. But this isn’t about how good plasma is. This isn’t even about Trump lying about how good plasma is (we’ve become somewhat immune to Trump lying). Our scientists and doctors from the best government scientific institutions are having to lie. Hahn tweeted today to half apologize.

Those that want to re-elect Trump heard him and a top doctor say that 35% fewer people will die now with convalescent plasma treatment. They also saw Trump’s tweet that the deep state is keeping therapeutics from the people. They don’t care about the details. Trump is more important than a few morals or what’s good for the country or scientific honesty.

And that is the story of a tiny turd caught in a shit storm that is heading for the fan, my dear children.

Could you be more specific?

The End of a Weird Summer

When school starts, summer ends. Even here in Texas where the summer weather doesn’t end – we could still have weeks of three digit highs ahead. But the easy living is over. On his school days, Evan has been waking as late as he can, around 7:45am. He spends 10 minutes with the soccer ball outside, then 10 minutes for breakfast, followed by 2 minutes for personal hygiene, before plonking himself down in front of his computer for a day at school. Today is the first Saturday after the first week of school. He’s sleeping in. A rare thunderstorm is rolling in. It is an hour past sunrise but it is still dark outside. Ouiser and I are sitting by the pool, watching the black clouds and the lightening flickering on the horizon. You can almost sense every fiber of nature reaching out towards the clouds willing them to drop their precious water on the parched earth.

We had a good summer. Different but good. It’s the first time I spent all summer in Texas in my 35 years here. We did nothing. Mornings outside with Ouiser and Evan, first with a soccer ball, and then in the pool. By nine or ten we were done outside for the rest of the day. I took a siesta in the afternoon while Evan and Vivian filled their heads with their newest anime obsession, My Hero Academia and Haikyu. At 7pm it is still in the mid-90’s outside. Sometimes Jo and I drove down for a socially distanced drink and chat outside Carol’s front porch. Or we’d go on a short walk with Vivian and Ouiser after sunset. Peyton stayed with us for a couple of weeks before her dorms opened at Texas State. Occasionally, Vivian and Peyton would get in the pool and stay there till well after the stars came out. Diners were served late and more often than I’d like to admit, followed by a trip to the store in Startzville to get everyone our own favorite pint of Ben & Jerry’s. After the kids turned in with their iPads and books, Jo and I stayed up and watched a Hercule Poirot or two on BritBox. Outside, the hill country turned from the bright emerald of spring to dull dark green and eventually yellow and brown. Expect for the blooms that love the heat. These beauties shine like beacons of color in the landscape.

A fox has taken up residence up the property near the driveway. Roadrunners zigzag the street carrying squirming lizards in their beaks. In the evening you can hear the distant lowing of the cows, and after darkness falls, the yelping of coyotes. Zeus and Skittles are ready to go outside and try to squeeze out any time someone opens the door. Jo bought them tiny harnesses and Evan has taken them out on “walks” wearing their harnesses and on leashes. But the cats, being the drama queens they are, pretend to collapse under the weight of their shackles and lay like boneless bits of cat fur on the grass. Ouiser roams the outside and mostly returns when called, only motivated by promises of doggy treats. She likes to swim in the pool for the heck of it. Every morning she asks to be let into the pool area, and then she swims around by herself. She also gets in when Evan is in the pool to play, but that is different from her solo swims.

The kids have started complaining that I don’t take photos of them any more. That after spending their entire lives whining when they see me point a camera in their direction. Now I only take pictures of the cats and dogs!

Evan’s school and Peyton’s college started the same week. So one morning we left Vivian in charge of Evan’s online education and lunch and drove Peyton and her stuff over to San Marcos. The Texas State campus is beautiful but they neglected to allow for kids to load and unload at the dorms. We eventually humped boxes and a dorm fridge up these stairs from an unmarked parking spot behind the dorm. I texted Vivian from the top of the stairs telling her she better start working out now so she can move herself into her college dorm in five years. Here’s a thought – what if five years from now we are still struggling with Covid. All physical colleges have ceased to exist. Vivian signs into her college class from the living room couch! There’s a nightmare.

The white wooden house is getting some tender love. We somehow selected renters with dogs both times we were gone and the dogs’ paws have scratched up the floors pretty badly. Floor people are coming in to sand down the floors. In a couple of weeks we will move into a house with pristine floors and this time our dog will scratch them up, dammit. Yesterday Jo and I drove down to Austin in the evening and moved all the furniture to the garage and bathrooms. In times like this I’m particularly thankful that Jo lifts and squats more than me!

When the house is ready we will move back to Austin. The weather will start cooling off and I can’t wait to socially distance and share a drink and grill with friends in the back yard. But I will miss the weird summer we spent in this place. And Ouiser will miss her morning swims.